Anti-Tau (phospho Thr181) Antibody [2A4]

The clone 2A4 monoclonal antibody from Antibodies.com specifically recognizes tau protein phosphorylated at threonine 181, an epitope linked to Alzheimer's disease pathology and investigated as a cerebrospinal fluid biomarker for neurodegenerative research. Produced in mouse hosts as an IgG2a isotype, this unconjugated primary antibody is supplied as 100 µg of lyophilised powder in a vial and is validated for western blot detection of tau in human and mouse samples.

Tau is a neuronal microtubule-associated protein whose abnormal hyperphosphorylation drives the formation of neurofibrillary tangles. The pThr181 site is one of several phospho-epitopes elevated in Alzheimer's brain tissue, and phospho-specific reagents such as clone 2A4 allow researchers to monitor this modification in cell lysates and brain homogenates. Western blot analysis with this antibody reveals phosphorylation-dependent shifts in tau banding patterns, supporting studies on kinase signaling, disease modeling, and tau-targeted therapeutic development.