Anti-Tau (phospho Thr181) Antibody [1A4]

This mouse IgG2a monoclonal antibody from Antibodies.com specifically recognizes the Tau protein when phosphorylated at threonine 181, an early post-translational modification associated with neurofibrillary pathology in Alzheimer's disease research. Clone 1A4 is supplied as 100 µg of lyophilised material and is validated for Western blot detection in both human and mouse samples, supporting comparative studies between patient-derived tissue and transgenic model systems. The unconjugated format allows flexible pairing with secondary reagents of the researcher's choice, including HRP- or fluorophore-conjugated anti-mouse IgG. Researchers working on tauopathy, neurodegeneration, and biomarker discovery commonly apply pThr181 detection to monitor disease progression and to characterize phosphorylation dynamics in cell-based and in vivo studies. For long-term activity, the reconstituted antibody should be stored at -20 °C, ideally in small aliquots to limit repeated freeze-thaw exposure. Reconstitution volume and recommended working dilutions are detailed on the accompanying product datasheet shipped with each vial.