Anti-Tau (phospho S422) Antibody

This rabbit polyclonal IgG reagent from Antibodies.com is raised against the microtubule-associated protein Tau phosphorylated at serine 422, a post-translational modification that accumulates in paired helical filaments and neurofibrillary tangles characteristic of Alzheimer's disease and other tauopathies. The unconjugated antibody is supplied as 200 µl, validated for Western blot detection of phospho-S422 Tau in human, mouse, and rat samples. Researchers working on tauopathy progression, Tau kinase signalling, or neurofibrillary pathology use this reagent to compare phosphorylated against total Tau burden in cell and tissue lysates, often alongside other phospho-site antibodies to stage tangle maturity. Aliquot upon first thaw and store refrigerated in working volumes to limit freeze-thaw cycles of the polyclonal stock.