Anti-Tau (phospho S422) Antibody

This unconjugated polyclonal reagent from Antibodies.com targets the microtubule-associated protein Tau at the phospho-S422 epitope, a post-translational modification linked to mature neurofibrillary tangle pathology in Alzheimer's disease and related tauopathies. Raised in rabbit and purified as an IgG preparation, the antibody is supplied in a 100 µl volume and is validated for Western blot detection of phosphorylated Tau in lysates derived from human, mouse, and rat neural tissue.

Researchers studying neurodegenerative mechanisms commonly apply this reagent to monitor S422 phosphorylation across disease models and postmortem brain samples. The polyclonal format offers recognition of multiple epitopes surrounding phospho-S422, which can be helpful when surveying heterogeneous patient-derived material. For long-term integrity, aliquot the antibody upon arrival and store at -20°C in working volumes to limit freeze-thaw cycles, and protect from light where practical. Pair with appropriate anti-rabbit secondary reagents for chemiluminescent or fluorescent Western blot readouts in research-use-only workflows.