Anti-Tau (phospho S396) Antibody

This rabbit polyclonal IgG antibody from Antibodies.com is raised against the microtubule-associated protein Tau phosphorylated at serine 396 (pS396), a modification enriched in neurofibrillary tangles and widely used as a marker of tau pathology in Alzheimer's disease research. Supplied as 50 µl of unconjugated reagent, the antibody is validated for western blot and immunohistochemistry applications and shows reactivity against human, mouse, and rat samples, supporting cross-species studies of tau phosphorylation in cultured neurons, brain tissue sections, and transgenic disease models. The polyclonal format recognises multiple epitopes around the phospho-S396 site, which can improve signal in IHC where epitope accessibility varies between tissue preparations. Researchers studying tauopathies commonly pair this reagent with antibodies against other phospho-epitopes, such as S202/T205 and T231, or against total tau to map disease-stage dependent phosphorylation patterns across cortex, hippocampus, and other vulnerable brain regions.