Anti-Tau (phospho S356) Antibody

Raised in rabbit against the microtubule-associated protein Tau, this polyclonal IgG reagent from Antibodies.com specifically recognizes the phosphorylated serine 356 epitope. It is validated for western blot and immunofluorescence workflows on human, mouse, and rat samples, and is supplied as an unconjugated 200 µl aliquot ready for use with secondary antibody detection chemistries of the researcher's choice. The phospho-S356 modification sits within Tau's fourth microtubule-binding repeat and is monitored in studies of Alzheimer's disease, frontotemporal dementia, and other tauopathies, where altered phosphorylation at this site correlates with pathological aggregation and axonal transport deficits. Applications include mapping S356 phosphorylation in cultured neurons by immunofluorescence, profiling phospho-Tau abundance across brain regions by western blot, and tracking how candidate kinase inhibitors shift S356 site occupancy in cell and animal models. For best stability, store at -20 °C in working aliquots to limit freeze-thaw cycles of the antibody stock.