Anti-Tau (Ab-396) Antibody

Raised in rabbit, this unconjugated polyclonal antibody recognizes the microtubule-associated Tau protein and is supplied by Antibodies.com as a 100 µl liquid format ready for laboratory use. The reagent binds epitopes on Tau expressed in human, mouse, and rat samples, enabling direct comparison of tau pathology or isoform biology between rodent models and patient-derived tissue.

Validated for Western blot and immunohistochemistry, the antibody supports experiments that resolve phosphorylated tau species on immunoblots and visualize tau immunoreactivity in fixed brain sections. Because the host species is rabbit, the reagent pairs cleanly with common anti-rabbit secondaries conjugated to HRP, biotin, or fluorophores, allowing chromogenic DAB development, fluorescence microscopy, or multiplexed tyramide-based staining protocols in IHC workflows.

Common research uses include investigation of Alzheimer's disease and related tauopathies, mapping of neurofibrillary tangle burden in post-mortem tissue, screening of compounds that influence tau aggregation or phosphorylation, and characterization of transgenic mouse lines engineered to express human tau isoforms. Researchers are advised to aliquot the vial upon arrival and refrigerate it short term, limiting freeze-thaw cycles to preserve polyclonal titer over the working life of the stock.