Anti-TARDBP Antibody

Produced in rabbit and supplied as an unconjugated polyclonal antiserum, this TARDBP-binding reagent from Antibodies.com targets the endogenous TAR DNA-binding protein 43, an RNA-binding protein linked to amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and several neurodegenerative proteinopathies. The immunogen-derived reactivity profile covers human, mouse, and rat samples, making the antibody suitable for cross-species studies of TDP-43 inclusion pathology in motor neurons and cortical tissue.

Validated for western blot, immunohistochemistry, and immunofluorescence workflows, the reagent is aliquoted at 100 µl per vial and is intended for research use only. Investigators commonly apply it to characterize full-length TDP-43, the ~35 kDa C-terminal fragment, and disease-associated phosphorylated or truncated species in cell lysates, frozen tissue sections, and cultured neurons.

Store at -20°C in working aliquots to limit freeze-thaw cycles, and protect from light when handling the unconjugated preparation. Pair with an HRP- or fluorophore-conjugated secondary antibody matched to rabbit IgG for downstream detection.