Anti-TARDBP Antibody

Raised in rabbit against TARDBP, this unconjugated polyclonal antibody from Antibodies.com is supplied at 1 mg/ml in a PBS buffer containing 0.1% sodium azide and 50% glycerol, packaged as a 100 µl vial. It is validated for western blot, immunohistochemistry, immunofluorescence, immunoprecipitation, and RNA immunoprecipitation workflows, and shows reactivity against human, mouse, and rat samples. TDP-43 is a nuclear DNA/RNA-binding protein whose cytoplasmic mislocalization and aggregation are hallmarks of amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and certain forms of Alzheimer disease, making this reagent useful for studies of RNA processing, stress granule dynamics, and neurodegeneration. The polyclonal format allows recognition of multiple epitopes, which is helpful when probing full-length protein or detecting pathological fragments and post-translationally modified species in cell or tissue lysates. As an unconjugated reagent, end users can couple it to their preferred fluorophore, enzyme, or bead system depending on the assay. For long-term storage, keep the glycerol-containing formulation frozen, and minimize freeze-thaw cycles by aliquoting on first use.