Anti-TAP2 Antibody

This rabbit polyclonal antibody targets TAP2 (Transporter 2, ATP-binding cassette sub-family B member 3), a critical subunit of the peptide transporter that shuttles cytosolic peptides into the endoplasmic reticulum for loading onto MHC class I molecules. Working in concert with TAP1, TAP2 contributes the peptide-binding pocket and the C-terminal ATPase domain that powers peptide translocation, making it useful for studying cytotoxic T-cell surveillance and viral immune evasion.

Provided by Antibodies.com as an unconjugated polyclonal reagent in a 100 µl vial at 1 mg/ml, this antibody is validated for western blot, immunohistochemistry, and immunofluorescence workflows. The cross-reactive profile covers Human, Mouse, and Rat samples, enabling comparative immunology studies in human cell lines and rodent disease models. The formulation is supplied in phosphate-buffered saline (PBS) at approximately pH 7.2 with 0.05% sodium azide added as a preservative; refrigerate short-term or aliquot and freeze for longer-term use to preserve activity.

Researchers use this reagent to investigate defective antigen presentation linked to bare lymphocyte syndrome type I, characterize MHC class I downregulation in tumor immune escape mechanisms, and follow peptide-loading complex assembly at the ER membrane. The polyclonal format recognizes multiple epitopes across the TAP2 protein, which can be useful when probing truncated or mutant variants in research use only settings.