Anti-TACC3 Antibody

TACC3 (Transforming Acidic Coiled-Coil Containing Protein 3) is a centrosome- and microtubule-associated protein that plays a central role in mitotic spindle assembly and chromosome alignment during cell division. This rabbit polyclonal antibody, supplied by Antibodies.com as a 100 µl aliquot, enables researchers to detect endogenous TACC3 protein across multiple experimental platforms, including western blot, immunohistochemistry, and immunofluorescence applications in both human and mouse samples.

The unconjugated format gives laboratories full flexibility to pair this reagent with their own secondary antibodies and label of choice, whether HRP, fluorophore, or biotin-based detection. TACC3 has emerged as a protein of strong interest in oncology research, where its dysregulation has been observed in breast, lung, ovarian, and colorectal tumour tissues, and where it serves as a marker for studying mitotic fidelity, centrosome amplification, and Aurora kinase signalling pathways. The polyclonal nature of the reagent offers broader epitope coverage than monoclonal alternatives, which is particularly useful when probing a protein whose post-translational modification state shifts through the cell cycle.

Storage at -20 °C in working aliquots is recommended to preserve activity across repeated freeze-thaw cycles, and the 100 µl volume supports several pilot optimisation runs before scaling up to larger cohort studies. Researchers investigating kinetochore-microtubule attachment errors, cancer cell proliferation assays, or developmental studies of early embryogenesis can apply this reagent to both fixed-cell imaging and standard lysis-based immunoblotting workflows.