Anti-TAB3 Antibody

TAB3 (TGF-beta-activated kinase 1-binding protein 3) functions as a scaffolding adaptor within the TAK1 kinase complex, partnering with TAB1 and TAB2 to recruit MAP3K7 and propagate signals that activate NF-kB and AP-1 downstream of TNF receptor, IL-1 receptor, and Toll-like receptor engagement. The rabbit polyclonal antibody offered by Antibodies.com against this target is supplied as 100 ul of unconjugated antiserum and has been validated for western blot and immunohistochemistry on human and mouse samples.

Because the reagent is polyclonal, it recognizes multiple epitopes across TAB3, which can increase sensitivity when target expression is low or when partial proteolysis is expected. The unconjugated format leaves detection chemistry open: researchers can pair it with HRP, fluorescent, or biotinylated secondary antibodies for chemiluminescent western blot membrane imaging or for chromogenic and fluorescent IHC staining of formalin-fixed tissue sections. Cross-species reactivity to both human and mouse TAB3 supports comparative work in cell line panels, primary immune cells, and tissue models of inflammation, innate immunity, and stress kinase signaling.

For best stability, store the vial refrigerated at 4 degrees C for routine use, and aliquot before freezing at -20 degrees C for long-term storage; repeated freeze-thaw cycles of the antiserum should be avoided to preserve binding activity. The 100 ul volume is sufficient for many western blot experiments and multiple IHC staining runs depending on dilution.