Anti-SYVN1 Antibody

Raised in rabbit against synoviolin 1, this unconjugated polyclonal reagent from Antibodies.com targets the endoplasmic reticulum-resident E3 ubiquitin ligase that drives ER-associated degradation (ERAD) of misfolded substrates. Researchers use it in Western blot and immunohistochemistry workflows on human samples to study SYVN1/HRD1 biology, including its regulation of Parkin in dopaminergic neuron models of Parkinson's disease, its role in rheumatoid arthritis synovial hyperplasia, and its emerging functions in tumor cell stress responses.

Supplied as 100 µl of liquid antiserum in a vial, the reagent is stored frozen at -20°C in working aliquots to limit freeze-thaw damage, with the IgG fraction directed against epitopes of human SYVN1. Validated sample types include cultured mammalian cell lysates for WB and paraffin-embedded tissue sections for IHC detection of ER-membrane SYVN1 expression.

Each lot is quality controlled and ships with documentation of host, clonality, and reactivity profile, supporting reproducible detection across cell biology, neurodegeneration, and immunology research projects.