Anti-SYT2 Antibody

Raised in rabbit as an unconjugated polyclonal IgG, this primary antibody recognizes endogenous synaptotagmin-2 (SYT2), an integral calcium-binding membrane protein of synaptic vesicles that serves as the principal fast Ca²⁺ sensor driving synchronous neurotransmitter release at presynaptic terminals. Validated for Western blot detection across human, mouse, and rat samples, it is supplied by Antibodies.com as a 200 µl aliquot per vial, with reactivity directed against the native endogenous SYT2 protein rather than recombinant fragments.

The reagent supports neuroscience and presynaptic biology research, including studies of synaptic vesicle exocytosis, neuromuscular junction function, and presynaptic differentiation in differentiated neuron models. Because loss-of-function mutations in SYT2 have been linked to Lambert-Eaton myasthenic syndrome and related neuromuscular disorders, well-characterized SYT2 detection reagents enable investigations into presynaptic calcium sensing in disease models. For Western blot applications, working aliquots should be stored at -20 °C and repeated freeze-thaw cycles avoided to preserve antibody reactivity. The reagent is intended for research use only and is not approved for diagnostic procedures.