Anti-Synuclein-α Antibody

Investigators studying Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy rely on robust detection tools for alpha-synuclein, the 140-amino-acid presynaptic protein whose aggregation into insoluble fibrils defines these synucleinopathies. This rabbit polyclonal antibody from Antibodies.com recognizes endogenous alpha-synuclein across human, mouse, and rat samples, enabling translational workflows spanning rodent disease models and postmortem clinical specimens. Validated applications include Western blot for the ~14 kDa monomer and higher-molecular-weight aggregates, immunohistochemistry on brain tissue for visualizing Lewy bodies and Lewy neurites, and ELISA quantification of soluble versus aggregated fractions. The unconjugated format allows flexible pairing with secondary detection reagents and custom labeling strategies. As a polyclonal reagent, the antibody binds multiple epitopes, which can be advantageous for detecting post-translationally modified or conformationally altered species, including the phosphorylated Ser129 variant commonly used as a marker of pathological inclusions. Supplied as 50 µl of liquid stock, the antibody should be stored refrigerated with working aliquots to limit freeze-thaw cycling and preserve binding activity across repeated experiments.