Anti-Synuclein-α Antibody

Manufactured by Antibodies.com as a primary antibody reagent, this affinity-purified reagent is raised in rabbit and is offered in a polyclonal format that specifically detects endogenous levels of Synuclein-α. The immunogen corresponds to a synthesized peptide derived from the human Synuclein-α sequence around the non-phosphorylation site of tyrosine 133, and the antibody is provided unconjugated at 1 mg/mL in a liquid PBS formulation containing 50% glycerol, 0.5% BSA, and 0.02% sodium azide. The product ships at 4°C and should be aliquoted and stored at −20°C upon receipt to avoid repeated freeze/thaw cycles. It is supplied in a 50 µL volume and is validated for ELISA, Western blot (WB), immunocytochemistry / immunofluorescence (ICC/IF), and immunohistochemistry (IHC), with reactivity confirmed against human, mouse, and rat samples. The antibody is intended for research use only and is not for diagnostic or therapeutic applications; it must be handled as a sodium azide-containing product with appropriate laboratory precautions. With the A34278 catalog designation, this polyclonal Synuclein-α reagent gives laboratories a reliable tool for investigating α-synuclein biology across multiple immunoassay platforms, whether probing Lewy body pathology markers on tissue sections, tracking endogenous protein expression in cell lysates, or localizing the protein by fluorescence microscopy. It is also useful for confirming phosphorylation-state-dependent binding since it was raised against a non-phosphorylated epitope region, making it a versatile complement to phospho-specific antibodies in studies of synucleinopathies such as Parkinson's disease and dementia with Lewy bodies.