Anti-Synaptotagmin Antibody

Synaptotagmin is a calcium-sensing transmembrane protein anchored on synaptic vesicle membranes that couples Ca²⁺ influx to fast, synchronous neurotransmitter release at presynaptic terminals. This polyclonal antibody from Antibodies.com targets the protein and is supplied as 100 µl of unconjugated rabbit antiserum, validated for western blot (WB), immunohistochemistry (IHC), and ELISA across human, mouse, and rat samples.

The reagent recognizes conserved cytoplasmic epitopes shared across Synaptotagmin isoforms, supporting reliable detection in hippocampal neuron cultures, brain tissue lysates, and transfected cell models. Its polyclonal format broadens epitope coverage across the tandem C2 calcium-binding domains, enabling studies of synaptic vesicle cycling, exocytosis kinetics, and the presynaptic release machinery in neuroscience research.

Researchers commonly apply this unconjugated reagent to characterize synaptic protein distribution, investigate isoform-specific trafficking, and probe how mutations in Synaptotagmin alter neurotransmitter release in models of neurodegeneration and neurological disease. Store refrigerated and protect from light to preserve activity; aliquot upon first use to limit freeze-thaw cycles.