Anti-SYN1 (phospho S549) Antibody

This rabbit polyclonal IgG reagent from Antibodies.com targets Synapsin-1 phosphorylated at serine 549, a regulatory site whose modification status is central to studies of neurotransmitter release and presynaptic plasticity. The antibody is supplied as 50 µl of unconjugated polyclonal IgG and validated for Western blot detection in human, mouse, and rat samples.

Phospho-specific recognition of SYN1 at S549 lets researchers track CaMKII- and PKA-driven signaling at the presynaptic terminal, supporting work on synaptic vesicle trafficking, activity-dependent remodeling, and neuronal differentiation in cultured neurons and brain tissue lysates.

Because the antibody is unconjugated, it pairs with HRP- or fluorophore-labeled secondary reagents chosen by the end user, and its cross-species reactivity profile covers the principal rodent model systems alongside human specimens, fitting into comparative neuroscience pipelines where SYN1 phosphorylation is the readout.