Anti-syk (Ab-323) Antibody

This rabbit polyclonal reagent from Antibodies.com specifically targets syk (Spleen Tyrosine Kinase), a 72 kDa non-receptor cytoplasmic tyrosine kinase that couples classical immunoreceptors bearing ITAM motifs to downstream calcium, PI3K, and MAPK cascades. The antibody was raised against a synthetic peptide spanning the region around residue 323 of human syk, enabling detection of the endogenous full-length kinase in cell lysates and fixed tissue sections. Application coverage includes Western blot analysis, immunohistochemistry on formalin-fixed paraffin-embedded specimens, and immunofluorescence staining of human cell lines. The unconjugated IgG is delivered in a 100 µl vial, sufficient for multiple immunoblots or stained coverslips at standard working dilutions. Researchers in hematology, immunology, and signal transduction rely on such reagents to map B-cell receptor signaling, mast cell degranulation, and the kinase's contribution to diffuse large B-cell lymphoma and related lymphoid malignancies.