Anti-SUV39H2 Antibody

Targeting the histone methyltransferase SUV39H2 (also designated KMT1B), this rabbit polyclonal reagent from Antibodies.com is supplied as an unconjugated antibody in a 100 µl vial. SUV39H2 catalyzes trimethylation of histone H3 at lysine 9, depositing the H3K9me3 chromatin mark linked to heterochromatin establishment, pericentric silencing, and transcriptional repression. The antibody has been validated for western blot (WB), immunohistochemistry (IHC), immunoprecipitation (IP), and chromatin immunoprecipitation (ChIP) workflows, with confirmed reactivity against human, mouse, and rat samples for cross-species studies of chromatin biology. Because SUV39H2 activity contributes to DNA methylation coupling, mitotic chromosome segregation, and is frequently dysregulated in solid tumors and leukemia, this reagent supports research into epigenetic gene silencing, heterochromatin maintenance, and chromatin-targeted therapeutic strategies in oncology.