Anti-Survivin Antibody

Survivin, encoded by the BIRC5 gene, is a 16.5 kDa member of the inhibitor of apoptosis (IAP) protein family that regulates both caspase activity and mitotic progression. This recombinant rabbit monoclonal reagent from Antibodies.com binds endogenous Survivin in mouse and rat samples and is supplied as a 100 µl liquid aliquot in TBS (pH 7.4) with 1% BSA, 40% glycerol, and 0.05% sodium azide as preservative.

The unconjugated antibody is validated for Western blot and immunohistochemistry workflows, supporting studies of tumor cell proliferation, chemoresistance mechanisms, and developmental tissue analysis. Researchers commonly apply it to characterize Survivin expression across carcinoma, lymphoma, and embryonic mouse models, where the protein is markedly upregulated relative to most differentiated adult tissues.

Store the vial at 4 °C for short-term use; for longer intervals, aliquot and freeze at -20 °C to preserve binding activity across multiple freeze-thaw cycles. The host species is rabbit, the clonality is monoclonal, and the unconjugated format offers flexibility for downstream labeling or signal-amplification strategies in comparative apoptosis research.