Anti-SUMO4 Antibody

Raised in rabbit against the Small Ubiquitin-like Modifier 4 (SUMO4) ubiquitin-family protein, this unconjugated polyclonal IgG reagent from Antibodies.com is supplied as a 50 µl aliquot of antiserum and validated for Western blot and immunofluorescence workflows. SUMO4 maps to chromosome 6q25 within the IDDM5 susceptibility interval, and the well-characterized M55V (A163G, rs237025) variant has been linked to type 1 diabetes in meta-analyses of Asian and European cohorts, producing a substitution at a conserved residue that elevates NF-κB transcriptional activity roughly five-fold and approximately doubles IL12B expression through altered conjugation of IκBα. The reagent detects endogenous SUMO4-conjugated substrates in human, mouse, and rat samples, enabling comparative sumoylation studies across orthologues and supporting work in cell lysates and fixed tissue sections. Applications include profiling NF-κB pathway activity, characterizing pancreatic islet biology, and exploring autoimmune signaling mechanisms where the SUMO4 M55V polymorphism has been implicated. Store at -20 °C in working aliquots to limit freeze-thaw cycles, refrigerate at 4 °C for short-term use, and protect from light to preserve reagent activity; for research use only.