Anti-SUMO2 / SUMO3 / SUMO4 Antibody

This polyclonal antibody from Antibodies.com targets the SUMO2, SUMO3, and SUMO4 proteins, members of the small ubiquitin-like modifier family involved in post-translational protein regulation. Raised in rabbit and supplied as 100 µl of unconjugated antiserum, the reagent is validated for western blot and immunohistochemistry workflows across human, mouse, and rat samples.

SUMO2 and SUMO3 share approximately 97% sequence identity, while SUMO4 shows more restricted expression, particularly in renal tissue, making a cross-reactive polyclonal reagent useful for comparative studies of sumoylation pathways. Researchers investigating stress response, transcriptional regulation, or cancer-associated sumoylation can apply this antibody to detect endogenous levels of both free SUMO paralogs and higher-molecular-weight conjugated SUMO chains on substrate proteins.

Storage at -20 °C in aliquots is recommended to preserve activity across repeated freeze-thaw cycles. The unconjugated format permits flexible pairing with custom fluorophore or enzyme labels, supporting both chromogenic immunohistochemistry and standard immunoblotting protocols. Each vial is intended for research use only and performs reliably in cell lysate and tissue-section preparations.