Anti-SUMO2 Antibody

Raised in rabbit, this unconjugated polyclonal reagent from Antibodies.com targets Small Ubiquitin-like Modifier 2 (SUMO2), a ubiquitin-family post-translational modifier central to stress response, nuclear transport, transcriptional regulation, and cell cycle progression. The antibody is supplied as 100 µl at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, ready for dilution in standard western blot, immunohistochemistry, and immunofluorescence protocols.

Validated reactivity covers human, mouse, and rat samples, supporting common mammalian model systems from cultured cell lysates to fixed tissue sections. Because SUMO2 shares substantial sequence identity with SUMO3, the polyclonal backbone typically recognizes SUMO2 as well as SUMO2/3 conjugates; confirmation by molecular weight and appropriate knockout controls is recommended when interpreting high-molecular-weight smears indicative of substrate modification.

For long-term stability, store the vial at -20°C and prepare working aliquots to limit freeze-thaw cycles. The unconjugated presentation permits flexible pairing with fluorescent, HRP, or biotinylated secondary reagents, and the polyclonal format offers broader epitope coverage than monoclonal alternatives when tracking diverse SUMOylated substrates. Intended for research use only, this primary antibody fits into proteostasis, DNA damage response, and chromatin remodeling studies where SUMO conjugation dynamics are under investigation.