Anti-SULT2A1 Antibody

Targeting the cytosolic sulfotransferase SULT2A1, this unconjugated rabbit polyclonal antibody from Antibodies.com recognizes an epitope on the human enzyme and is validated for Western blot and immunohistochemistry. SULT2A1 is the principal hepatic and adrenal sulfotransferase responsible for sulfonating hydroxysteroids such as DHEA, pregnenolone, and bile acids, so reliable detection of the protein matters for studies of androgen metabolism, xenobiotic clearance, and bile acid homeostasis.

Supplied as 100 µl of polyclonal antiserum raised in rabbit, the reagent is unconjugated to give labs freedom to attach HRP, biotin, or fluorophores suited to their detection chemistry. Reported research applications include profiling SULT2A1 levels in hepatocellular carcinoma tissue, adrenal cortex sections, intestinal epithelium, and steroid-responsive cancer cell lines where altered sulfotransferase activity has been linked to tumor progression, nonalcoholic fatty liver disease, and individual variation in drug conjugation capacity.

For best results, aliquot the antiserum on first use to limit freeze-thaw cycles, store refrigerated between uses, and titrate against endogenous human SULT2A1 signals in positive-control lysates. Reactivity has been confirmed against the human target, making this antibody suitable for translational and basic research workflows that compare SULT2A1 expression across patient-derived samples, primary hepatocytes, and in vitro models.