Anti-STX2 Antibody

Affinity-purified polyclonal reagent raised in rabbits against Syntaxin-2 (STX2/epimorphin), an integral t-SNARE membrane protein that localizes to the apical plasma membrane and drives vesicle fusion events underlying epithelial morphogenesis, midbody abscission during cytokinesis, and Ca2+-regulated exocytosis. Supplied from Antibodies.com as 100 µl of unconjugated liquid antisera, the reagent is validated for western blot and immunohistochemistry on human and mouse samples, where STX2 migrates near 33-36 kDa. Because the IgG is delivered without a reporter label, end users can conjugate it to HRP, biotin, or a fluorophore of choice and pair it with rabbit-IgG secondary reagents in immunofluorescence, immunoprecipitation, or ELISA workflows. A synthetic peptide immunogen corresponding to residues of human STX2 supports recognition of full-length protein and the alternatively spliced isoforms STX2A, STX2B, and STX2C commonly expressed in epithelial and neuronal preparations. Studies on epithelial-mesenchymal interactions, lung surfactant secretion, sperm acrosomal exocytosis, and SNARE complex assembly at the cleavage furrow benefit from this flexible building block for chromogenic and fluorescent staining panels. Aliquot the vial upon arrival, refrigerate to preserve binding activity, protect from light, and minimize freeze-thaw cycles across multiple immunoblot and IHC sessions.