Anti-STX11 Antibody

Rabbit polyclonal antibody targeting Syntaxin 11 (STX11), a t-SNARE protein essential for vesicle fusion and cytotoxic granule exocytosis in natural killer cells and cytotoxic T lymphocytes. Produced by Antibodies.com, this unconjugated primary antibody is validated for Western blot (WB) and immunohistochemistry (IHC) workflows and shows reactivity against human and mouse samples, supporting studies of immune synapse formation, secretory lysosome trafficking, and the molecular basis of familial hemophagocytic lymphohistiocytosis type 4 (FHL4), where loss-of-function STX11 mutations impair lymphocyte cytotoxicity.

Supplied as 100 µl of polyclonal antiserum raised in rabbit, the reagent is delivered in unconjugated format for flexible pairing with secondary detection systems. STX11 operates as part of SNARE complexes on secretory lysosomes, and this antibody enables detection of endogenous protein in cell lysates and fixed tissue sections, useful for probing NK-cell degranulation, vesicle trafficking, and immune cell signaling research.