Anti-STUB1 Antibody

This polyclonal rabbit antibody from Antibodies.com targets STUB1, an E3 ubiquitin ligase also known as CHIP that functions as a co-chaperone of Hsp70 and Hsp90 in cellular protein quality control. STUB1 ubiquitinates misfolded or damaged client proteins and directs them toward proteasomal degradation, and has been studied in the context of neurodegeneration, cardiac stress responses, and tumor suppression pathways.

The unconjugated reagent is supplied as a 100 µl vial and is validated for western blot (WB) and immunohistochemistry (IHC) workflows. It has been verified for reactivity against human, mouse, and rat samples, supporting cross-species studies of chaperone biology and ubiquitin–proteasome signaling. Being a polyclonal antibody raised in rabbit, the reagent recognizes multiple epitopes on the STUB1 target, which is useful when probing expression changes across experimental conditions or different tissue types.

Researchers investigating heat-shock protein regulation, stress-induced protein turnover, or E3 ligase involvement in disease models can apply this antibody to detect endogenous STUB1 in cell lysates, tissue homogenates, or fixed sections. Its unconjugated format also leaves the door open for downstream labeling with secondary reporters of the researcher's choice, and the 100 µl pack size offers enough volume for multiple optimization runs alongside routine screening.