Anti-STMN3 Antibody

Supplied by Antibodies.com as 200 µl of unconjugated rabbit polyclonal IgG, this primary antibody targets STMN3 (Stathmin-3), a neuronal member of the stathmin family of phosphoproteins that sequesters free tubulin heterodimers and destabilizes microtubule plus-ends. It is validated for Western blot detection of endogenous human STMN3 in cell lysates, brain tissue homogenates, and cultured neuronal models. The polyclonal format increases the probability of recognizing multiple epitopes across the 21 kDa target, supporting consistent chemiluminescent readouts in standard SDS-PAGE workflows.

STMN3, also referred to as SCLIP (SCG10-Like Protein), is enriched in the hippocampus, cortex, and cerebellum, where it localizes to vesicle-like structures that track dynamic microtubules. Published work has linked it to axonal branching, growth cone remodeling, and Purkinje cell dendritic arborization. Beyond neuronal biology, STMN3 has been identified as a STAT3-interacting partner whose microtubule-destabilizing activity is antagonized by STAT3 binding, and elevated expression has been reported in glioma, breast cancer, and ovarian cancer contexts, where it contributes to tumor cell migration and invasion. Researchers studying cytoskeletal dynamics during neurogenesis, models of neurodegenerative disease, or STAT3-dependent tumor migration will find this reagent useful for monitoring STMN3 protein levels alongside complementary molecular readouts.

Store the vial refrigerated at 4 °C for short-term use; for longer-term storage, aliquot and freeze at -20 °C, avoiding repeated freeze-thaw cycles. The reagent is supplied as a single-use liquid aliquot in a standard vial format and is intended for research use only.