Anti-STK39 Antibody

STK39, also known as SPAK (STE20/SPS1-related proline-alanine-rich kinase), is a serine/threonine kinase that phosphorylates conserved threonine residues in the N-terminal regulatory domains of the cation-chloride cotransporters NKCC1, NKCC2, and KCC3. This polyclonal rabbit IgG antibody from Antibodies.com is supplied as an unconjugated reagent in a 200 µl volume and is validated for Western blot detection across human, mouse, and rat samples.

The STK39 gene maps to chromosome 2q24.2, and single-nucleotide variants at this locus have been linked to blood pressure regulation and hypertension susceptibility in genome-wide association studies. STK39 signaling is also a subject of investigation in cytoskeleton remodeling, cell migration, and renal tubular ion transport research, supporting its relevance to vascular and renal physiology studies.

Because the reagent is unconjugated, researchers can pair it with HRP-, biotin-, or fluorophore-conjugated secondary reagents for chemiluminescent or fluorescence-based immunoblotting workflows. The polyclonal format provides recognition of multiple epitopes on STK39, which can improve signal robustness across denatured lysate preparations compared with monoclonal alternatives.