Anti-STIP1 Antibody

This rabbit polyclonal antibody targets STIP1 (Stress-Induced Phosphoprotein 1), a 63 kDa co-chaperone also known as HOP that physically links Hsp70 and Hsp90 through three tetratricopeptide repeat (TPR) domains, coordinating client-protein transfer between the two chaperone systems. Antibodies.com supplies the reagent in unconjugated format at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol as a cryoprotectant, and the 100 µl vial is sized for routine immunoprecipitation and chromatin work where larger input volumes are required. The polyclonal antibody recognizes the human, mouse, and rat STIP1 protein, and it has been validated by Antibodies.com for western blot, immunohistochemistry, immunofluorescence, immunoprecipitation, and RNA immunoprecipitation. STIP1 biology is studied in models of neurodegeneration, glucocorticoid receptor signaling, and several carcinomas, including breast and hepatocellular tumors where elevated STIP1 levels correlate with proliferation and stress adaptation. For handling, store the vial at -20 °C in working aliquots to limit freeze-thaw cycles, protect from light, centrifuge briefly before opening, and dilute into PBS or blocking buffer immediately before use. The 50% glycerol formulation keeps the antibody liquid at -20 °C, so aliquots do not need to be stored frozen solid. Research use only.