Anti-Stathmin1 (Ab-16) Antibody

Stathmin1 is a 17 kDa cytoplasmic phosphoprotein that destabilizes microtubules and regulates cell cycle progression, particularly during mitosis. This polyclonal antibody from Antibodies.com is raised in rabbit and recognizes Stathmin1 as the Ab-16 reagent. The antibody is unconjugated and supplied as 100 µl of liquid, ready for use in western blot (WB) and immunohistochemistry (IHC) workflows on human, mouse, and rat samples.

Researchers studying cytoskeletal dynamics, mitotic spindle assembly, and oncogenic transformation frequently use Stathmin1-targeting reagents because Stathmin1 phosphorylation state modulates microtubule plus-end catastrophe rates. Loss of Stathmin1 function stabilizes microtubules and arrests cells at G2/M, while overexpression in many tumor types correlates with altered chemoresponse and disease progression.

Validated applications include western blotting to detect the ~17 kDa band in cell lysates and immunohistochemistry on formalin-fixed paraffin-embedded tissue sections. The polyclonal nature of the reagent enables recognition of multiple epitopes across the target, supporting signal robustness when probing for full-length Stathmin1 versus specific phospho-forms.

For handling, refrigerate the antibody upon receipt and protect from light to preserve activity. For long-term storage, aliquot and freeze the reagent, avoiding repeated freeze-thaw cycles. The unconjugated format allows researchers to couple the antibody to a preferred fluorophore, biotin, or enzyme for custom detection in immunofluorescence, chromogenic IHC, or western blot protocols.