Anti-Stat5b Antibody

Stat5b is a critical member of the STAT family of transcription factors that mediates cytokine and growth factor signaling through the JAK-STAT pathway, influencing gene expression in immune cells, mammary tissue, and hepatic metabolism. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against Stat5b and validated for use in western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat samples.

The antibody is supplied as 100 µl of liquid stock at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol as a cryoprotectant, supporting short-term storage at 4 °C and longer-term aliquoted storage at -20 °C without repeated freeze-thaw cycles. The polyclonal format broadens epitope coverage on Stat5b, which is useful when probing both phosphorylated and total protein in signaling studies, prolactin and growth hormone research, and investigations into hematological malignancies where aberrant Stat5 activity has been documented.

Researchers commonly deploy this reagent to examine Stat5b activation downstream of cytokines such as IL-2, IL-7, and IL-15, to chart lymphocyte differentiation in T and NK cells, and to compare Stat5b expression against its close paralog Stat5a in tissue sections. The unconjugated format supports flexible pairing with custom fluorophores, HRP conjugates, or biotin labels depending on the detection chemistry required.