Anti-STAT5A Antibody

This rabbit polyclonal reagent from Antibodies.com targets STAT5A, a transcription factor activated downstream of cytokine and growth factor receptor signaling through the JAK-STAT pathway. Phosphorylation at tyrosine 694 drives STAT5A dimerization, nuclear translocation, and transcriptional regulation of genes controlling mammary epithelial differentiation, prolactin responses, and lymphocyte proliferation.

The unconjugated IgG antibody is supplied as 100 µl of polyclonal antibody and is validated for western blot and immunohistochemistry on human and mouse samples. Researchers use it to probe phosphorylated and total STAT5A pools in mammary tissue, hematopoietic lineages, and tumor models where dysregulated JAK-STAT signaling contributes to leukemogenesis and solid tumor progression.

Storage at -20 °C in small aliquots preserves antibody activity across multiple freeze-thaw cycles, and the unconjugated format allows direct coupling to fluorophores, biotin, or enzymes depending on the downstream assay requirement.