Anti-Stat5 Antibody

Stat5 (Signal Transducer and Activator of Transcription 5) is a cytoplasmic transcription factor that becomes phosphorylated and dimerizes upon cytokine or growth factor receptor activation, then translocates to the nucleus to drive gene expression. Antibodies.com offers this rabbit polyclonal reagent for researchers investigating the JAK-STAT signaling axis across human, mouse, and rat model systems.

Validated for Western blot, immunohistochemistry, and ELISA workflows, the unconjugated antibody is supplied as 100 µl of polyclonal antiserum raised in rabbit. The reagent is commonly used to probe phosphorylation-dependent activation, isoform-specific expression of Stat5a/Stat5b, downstream transcriptional responses to prolactin, growth hormone, erythropoietin, and interleukins such as IL-2 and IL-7, and the contribution of constitutive Stat5 signaling in leukemia and lymphoma research.

Laboratories studying mammary gland development, hematopoiesis, regulatory T cell biology, and cytokine-driven proliferation rely on this reagent to track both total Stat5 protein and activated, phosphorylated species in cell lysates and tissue sections. The polyclonal format broadens epitope coverage and tolerates minor sequence variation between species, supporting comparative studies in rodent inflammation and tumor models.

For storage and handling, the antibody should be kept refrigerated with aliquots prepared to limit freeze-thaw cycles, and protected from light to preserve reagent integrity over the working shelf life.