Anti-Stat3 (P699) Antibody

Phospho-specific rabbit polyclonal antibody that recognizes Signal Transducer and Activator of Transcription 3 (Stat3) at the P699 phosphorylated residue, supplied by Antibodies.com as an unconjugated reagent at 1 mg/ml in Phosphate buffered saline with 0.05% sodium azide at approximately pH 7.2. This reagent targets the activated form of Stat3, a key transcription factor in the JAK-STAT signaling cascade that mediates cellular responses to cytokines such as IL-6, IL-10, and growth factors including EGF.

Validated for Western Blotting and Immunohistochemistry, the antibody reacts with Human, Mouse, and Rat samples, supporting cross-species studies in oncology, immunology, and inflammation research. Phosphorylated Stat3 is a hallmark of constitutive pathway activation in many tumor types and is widely investigated as a downstream readout of cytokine receptor signaling.

The product is provided as a 50 µl volume and is intended for detection of activated Stat3 in cell lysates by WB and in fixed tissue sections by IHC. The polyclonal format offers broader epitope recognition across the phosphorylated target, which can be advantageous when monitoring pathway activation under varying stimulation conditions.