Anti-Stat3 (P699) Antibody

A rabbit polyclonal antibody from Antibodies.com raised against the STAT3 transcription factor, an intracellular mediator of cytokine and growth factor signaling through the JAK-STAT pathway. The reagent is supplied as 100 µl at 1 mg/ml in phosphate buffered saline (PBS) containing 0.05% sodium azide at approximately pH 7.2, unconjugated for flexible detection chemistry in Western blot and immunohistochemistry workflows.

Reactivity has been confirmed in human, mouse, and rat samples, supporting translational studies that compare signaling across species, including rodent disease models and clinical tissue specimens. STAT3 is a frequent experimental target in cancer biology, where it is probed downstream of interleukin-6 and EGF receptor activation, and in immunology, where it is used to characterize T helper 17 cell differentiation and cytokine-driven transcriptional programs.

The polyclonal format recognizes multiple epitopes on the STAT3 protein, which can improve detection when a single residue is occluded by post-translational modification or when distinguishing between splice isoforms. The antibody should be stored refrigerated in the original vial, and aliquoting upon first use is recommended to limit repeated freeze-thaw cycles over long project timelines.