Anti-Stat3 Antibody

This rabbit polyclonal antibody targets Signal Transducer and Activator of Transcription 3 (STAT3), an approximately 88 kDa transcription factor that mediates signaling downstream of cytokines, interleukins, and growth factors. Upon phosphorylation at tyrosine 705, STAT3 dimerizes, translocates to the nucleus, and regulates genes involved in cell proliferation, survival, differentiation, and immune responses. Constitutively active STAT3 signaling is frequently observed in both solid tumors and hematological malignancies, and the pathway is a focus of oncology, immunology, and signal transduction research.

From Antibodies.com, the reagent is supplied as 100 µl of unconjugated rabbit polyclonal antiserum and is validated for Western blot, immunohistochemistry, and ELISA workflows. It cross-reacts with human, mouse, and rat samples, making it suitable for comparative studies across model systems and primary tissue. Investigators routinely deploy anti-STAT3 reagents to probe phosphorylation status, downstream gene activation, and pathway dysregulation in cancer cell lines, tumor xenografts, and inflammatory disease models.