Anti-STAT2 Antibody

This rabbit polyclonal IgG antibody recognizes human STAT2 (Signal Transducer and Activator of Transcription 2), a ~113 kDa transcription factor central to type I interferon signaling. Upon IFN-α/β stimulation, STAT2 is phosphorylated, recruits STAT1 and IRF9 to form the ISGF3 complex, and translocates to the nucleus to drive expression of interferon-stimulated genes involved in antiviral defense.

Provided by Antibodies.com as an unconjugated reagent in a 200 µl volume, the antibody is validated for Western blot and immunohistochemistry workflows. It is raised in rabbit, formatted as a polyclonal IgG, and reacts with human STAT2, making it a practical reagent for laboratories investigating JAK-STAT pathway activity, innate immune signaling, viral response mechanisms, and STAT2 involvement in oncology and inflammatory disease models.

The unconjugated format gives researchers flexibility to pair the antibody with their own secondary conjugates and detection chemistries, including HRP, biotin, or fluorophore-labeled secondaries depending on the platform. Store refrigerated and protect from light for long-term stability; aliquot upon first thaw to limit freeze-thaw cycles and preserve reagent performance.