Anti-STAT2 Antibody

STAT2 (Signal Transducer and Activator of Transcription 2) is a cytoplasmic transcription factor central to type I interferon signaling. After IFNα/β receptor activation by JAK kinases, STAT2 is phosphorylated, dimerizes with STAT1, and pairs with IRF9 to assemble the ISGF3 complex, which translocates into the nucleus to induce interferon-stimulated genes (ISGs). This unconjugated rabbit polyclonal antibody from Antibodies.com targets human STAT2 and is validated for Western blot (WB) and immunohistochemistry (IHC) workflows, providing a specific reagent for studies of innate antiviral immunity, viral pathogenesis, JAK/STAT pathway dysregulation, and tumor immunogenicity.

Supplied as 100 µl of polyclonal IgG antibody, the unconjugated Primary Antibody format detects endogenous STAT2 in human cell lysates and formalin-fixed tissue sections. Investigators probing SARS-CoV-2 susceptibility, ISG induction kinetics, and host-pathogen interaction models apply such STAT2 antibodies to track total and phosphorylated protein across immunoblotting and chromogenic staining platforms. Intended for research use only, the unconjugated format keeps secondary antibody pairing and detection chemistry fully open, accommodating HRP/DAB or fluorescence IHC setups in human tissue.