Anti-Stat1 Antibody

Stat1 (Signal Transducer and Activator of Transcription 1) is a critical transcription factor in the JAK-STAT signaling cascade, mediating cellular responses to type I, II, and III interferons and numerous cytokines. This unconjugated rabbit polyclonal antibody from Antibodies.com recognizes the human Stat1 protein and is supplied as 100 µl of ready-to-use reagent suitable for western blot, immunohistochemistry, and ELISA workflows.

The antibody is raised in rabbit and validated for research applications requiring detection of endogenous Stat1. It reacts with human samples and is used in immunoblotting, where it detects the two major Stat1 isoforms (approximately 84 kDa and 91 kDa) on SDS-PAGE. Researchers studying antiviral responses, cytokine signaling, innate immunity, and tumor immunology rely on Stat1 detection to monitor expression and activation status, including phosphorylation at Tyr701.

For immunohistochemistry, the reagent is applied to formalin-fixed paraffin-embedded tissue sections to localize Stat1 expression in normal and diseased samples. The unconjugated format provides flexibility in secondary antibody choice and detection chemistry, supporting both fluorescence and chromogenic protocols. This product is intended for research use only.