Anti-Stat1 Antibody

This polyclonal reagent from Antibodies.com targets STAT1 (Signal Transducer and Activator of Transcription 1), a ~91 kDa transcription factor central to interferon-mediated signaling. Produced in rabbit and supplied in a vial as 100 µl of unconjugated antiserum, it is validated for Western blot, immunohistochemistry, immunoprecipitation, and ELISA workflows. Cross-reactivity spans human, mouse, rat, and monkey samples, supporting comparative studies in rodent disease models and primate tissue panels. STAT1 is phosphorylated on tyrosine 701 and serine 727 following IFN-α, IFN-β, or IFN-γ stimulation, driving dimerization, nuclear translocation, and induction of interferon-stimulated genes involved in antiviral defense, antigen presentation, and tumor surveillance. Researchers employ this antibody to track basal versus activated STAT1 levels, dissect JAK-STAT pathway output in cytokine-treated cells, and evaluate pathway status in tumor biopsies or inflammatory lesions. Store at -20°C in working aliquots to limit freeze-thaw cycles, and minimize exposure to light. The unconjugated format provides flexibility for custom labeling, chromogenic detection, or amplification strategies when studying innate immune signaling, viral infection models, or autoimmune pathology.