Anti-ST3GAL3 Antibody

ST3GAL3 is a Golgi-resident type II transmembrane sialyltransferase that transfers sialic acid from CMP-N-acetylneuraminate to terminal galactose residues on glycoproteins and glycolipids. Also referenced in the literature as SIAT4C or ST3N, the enzyme is primarily responsible for constructing the sialyl Lewis a (sLea) epitope and contributes to selectin ligand biosynthesis on leukocyte and endothelial glycoconjugates, linking its activity to inflammatory cell rolling and lymphocyte homing. Loss-of-function variants in ST3GAL3 have been identified in patients with early-onset epilepsy and neurodevelopmental impairment, and altered ST3GAL3 expression has been reported in several solid tumor contexts, making the protein a frequent subject of glycobiology, neurobiology, and oncology investigations.

This rabbit polyclonal reagent from Antibodies.com is supplied as 100 µl of unconjugated antiserum suitable for Western blot and immunofluorescence workflows on human, mouse, and rat samples. Researchers commonly apply the antibody to confirm endogenous ST3GAL3 protein levels in cell lysates by immunoblotting and to map subcellular Golgi localization by IF imaging. Aliquot upon arrival to limit freeze-thaw cycles and store refrigerated between uses to preserve antibody activity; the reagent is intended for research use only.