Anti-SSR4 Antibody

This polyclonal antibody from Antibodies.com targets SSR4 (Signal Sequence Receptor Subunit 4), a component of the TRAP (translocon-associated protein) complex embedded in the endoplasmic reticulum membrane. Raised in rabbit and of IgG isotype, the reagent is unconjugated and supplied as 200 µl of liquid antiserum intended for western blot detection of the human and mouse target protein.

SSR4 operates as the delta subunit of the TRAP complex, where it associates with the Sec61 translocon to assist the translocation and processing of nascent secretory and membrane-bound polypeptides. Loss-of-function mutations in the SSR4 gene are linked to a congenital disorder of glycosylation (SSR4-CDG, formerly CDG-Iy), underlining its importance for ER-associated protein folding and quality control.

Applications include western blot analysis of whole-cell lysates and microsomal membrane fractions under standard SDS-PAGE and electroblotting conditions. The cross-reactivity profile covers Human and Mouse, supporting comparative work in cell lines, primary tissues, and disease models that probe secretory pathway function, translocon composition, or ER stress responses.