Anti-SSR1 Antibody

The SSR1 (Signal Sequence Receptor 1) primary antibody from Antibodies.com is a rabbit polyclonal reagent raised against the SSR1 subunit of the translocon-associated protein (TRAP) complex in the endoplasmic reticulum membrane. Purified as an IgG preparation and supplied as an unconjugated 200 µl liquid aliquot, this polyclonal reagent is validated for western blot detection of endogenous SSR1 in both human and mouse samples.

SSR1, also known as TRAP-alpha, functions in the translocation of nascent polypeptides into the ER lumen and associates with the Sec61 translocon. Investigators studying protein targeting into the secretory pathway, ER-associated quality control, or membrane insertion mechanisms commonly use anti-SSR1 antibodies as a marker for TRAP complex integrity. The antibody cross-reacts with SSR1 from human and mouse, supporting broad use across common mammalian cell culture systems and tissue models.

Recommended storage is at -20 °C in working aliquots to limit repeated freeze-thaw cycles, with brief refrigeration for short-term use. For western blot applications, typical dilution ranges from 1:500 to 1:2000 depending on expression level, using an HRP- or fluorophore-conjugated anti-rabbit IgG secondary reagent for detection. As a polyclonal reagent, this antibody offers broader epitope recognition than monoclonal alternatives, supporting consistent detection across SSR1 splice variants.