Anti-SSH3 Antibody

Produced by Antibodies.com, this rabbit polyclonal antibody recognizes human SSH3 (Slingshot Homolog 3), a dual-specificity phosphatase involved in cofilin dephosphorylation and actin filament remodeling. The unconjugated reagent is supplied as 100 µl aliquots and is validated for western blot (WB) and immunohistochemistry (IHC) on human samples, making it a practical reagent for cytoskeleton, cell migration, and signaling research.

SSH3 contributes to actin cytoskeleton dynamics by reactivating cofilin at the leading edge of motile cells, supporting lamellipodium formation and turnover of filamentous actin. The protein is studied in contexts ranging from neuronal development and axon guidance to cancer cell invasion and leukocyte chemotaxis, where its phosphatase activity influences cytoskeletal reorganization and downstream signaling events.

Each antibody preparation is affinity-purified and quality tested, with reactivity expected against endogenous SSH3 in human cell lysates and tissue sections. Researchers commonly apply the antibody at optimized dilutions for clean band detection in WB at the predicted molecular weight and for specific cytoplasmic staining patterns in IHC.