Anti-SRPX Antibody

Polyclonal rabbit IgG raised against the sushi-repeat containing X-linked (SRPX) protein, supplied by Antibodies.com as an unconjugated, liquid-format reagent for research use only. Each vial contains 100 µl at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, a cryoprotective mix that supports storage at -20°C with minimal freeze-thaw damage. The antibody has been validated for Western blot and immunohistochemistry applications and reacts with SRPX orthologs from human, mouse, and rat tissue, enabling comparative studies across model species and patient samples.

SRPX is a secreted extracellular matrix and cell-surface glycoprotein best known for its role in neuronal migration, synapse formation, and the regulation of angiogenesis through uPAR-mediated signaling. Mutations in SRPX are linked to rolandic epilepsy with speech dyspraxia, and altered expression has been reported in glioblastoma and colorectal tumor microenvironments, where the protein contributes to vascular remodeling. Laboratories working on these pathways use the antibody to detect endogenous SRPX in brain, vascular, and tumor tissue lysates and to localize the protein in formalin-fixed paraffin sections.

Format summary: host rabbit, clonality polyclonal, conjugate unconjugated, isotype IgG, buffer PBS pH 7.4 with 0.1% sodium azide and 50% glycerol. Shipped on blue ice; store aliquots at -20°C and avoid repeated freeze-thaw cycles to preserve immunoreactivity.