Anti-SRP14 Antibody

SRP14 is a 14 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the co-translational targeting of nascent secretory and integral membrane proteins to the endoplasmic reticulum. This unconjugated IgG polyclonal reagent from Antibodies.com was raised in rabbit and is validated for Western blot detection of the human SRP14 protein.

The antibody is supplied as a 100 µl liquid aliquot and is intended for research use only, supporting studies of protein translocation, ER targeting, and translational regulation. SRP14 forms a stable heterodimer with SRP9 at the Alu domain of the SRP, contributing to the elongation arrest function that pauses ribosomes during membrane protein biogenesis.

Pairing this antibody with appropriate whole-cell lysates allows visualization of SRP14 at its expected molecular weight near 14 kDa. Researchers investigating ribosomal pausing, cotranslational translocation, or early secretory pathway biogenesis will find this reagent useful for probing steady-state SRP14 levels across different human cell lines and primary cultures.