Anti-SREBP-1 Antibody

Produced in rabbit as an unconjugated polyclonal reagent and supplied as a 100 µl liquid aliquot, this Sterol Regulatory Element-Binding Protein 1 (SREBP-1) antibody from Antibodies.com supports Western blot, immunohistochemistry, and ELISA workflows against human and rat samples. SREBP-1 is a basic-helix-loop-helix-leucine zipper transcription factor that drives fatty acid and cholesterol biosynthesis by engaging sterol regulatory elements in the promoters of lipogenic target genes. The antibody recognizes multiple epitopes across the protein, covering both the ~125 kDa membrane-bound precursor and the ~68 kDa mature nuclear fragment generated by Golgi-resident proteases. Researchers apply this reagent to liver, adipose, and pancreatic lysates to track SREBP-1 activation in models of hepatic steatosis, insulin resistance, and tumor metabolism, often alongside readouts of downstream targets such as fatty acid synthase (FASN) and acetyl-CoA carboxylase (ACC). The unconjugated format allows flexible pairing with HRP, biotin, or fluorophore-conjugated secondary reagents selected by the end user. For storage, keep refrigerated and protect from light; aliquot upon first thaw to limit freeze-thaw cycles and preserve binding activity. The polyclonal nature of the reagent provides robust signal across variable antigen expression, and each lot is calibrated for standard immunoblotting and immunostaining protocols. Host: Rabbit. Clonality: Polyclonal. Reactivity: Human, Rat. Conjugate: Unconjugated. Target: SREBP-1.