Anti-SREBF2 Antibody

This unconjugated rabbit polyclonal IgG antibody from Antibodies.com targets SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2), a membrane-bound transcription factor that governs cholesterol biosynthesis and lipid homeostasis in mammalian cells. Under low sterol conditions, the full-length precursor is cleaved and the active fragment translocates to the nucleus to drive expression of genes in the cholesterol synthesis pathway, including HMGCR and LDLR. The reagent is validated for immunohistochemistry (IHC) on formalin-fixed tissue sections from human, mouse, and rat samples, supporting research into hepatic lipid metabolism, atherosclerosis models, and broader metabolic disease studies. Supplied at 200 µl, the antibody can be paired with the end user's preferred secondary detection system or custom fluorophore conjugation workflows. The IgG isotype ensures broad compatibility with standard anti-rabbit secondary reagents used across immunostaining protocols. For research use only; storage at -20 °C in aliquoted form preserves activity through multiple freeze-thaw cycles.